Necrotizing sialometaplasia ns is a benign, selflimiting inflammatory reaction of salivary gland tissue which may mimic squamous cell carcinoma or mucoepidermoid carcinoma, both clinically and histologically, that creates diagnostic dilemma leading to unwarranted aggressive surgery. Necrotizing sialometaplasia of the hard palate in a. This condition holds diagnostic importance because of its clinical and histopathological presentation, which is ambiguous, and can be misdiagnosed as carcinoma particularly squamous cell carcinoma or mucoepidermoid carcinoma. Necrotizing sialometaplasia of the parotid gland in a dog hayoung kim, gyehyeong woo, youchan bae,1 yeonhee park, yiseok joo abstract. Sonstige epitheliale nichtentzundliche veranderungen springerlink. The aim of this article is to report a case of necrotizing sialometaplasia with long term followup. Necrotizing sialometaplasia ns is a benign, self limiting inflammatory reaction of salivary gland tissue which may mimic squamous cell carcinoma or mucoepidermoid carcinoma both clinically and histologically and can lead to unnecessary surgical approach. Pdf necrotizing sialometaplasia ns is a selflimiting inflammatory disease, that involves salivary glands, more frequently the minor ones. Some predisposing factors such as smoking, use of alcohol, denture wearing, recent surgery, traumatic injuries. International journal of dental sciences and research 6, no. Necrotizing sialometaplasia is an important lesion as it can be misdiagnosed as a malignancy. The cause of necrotizing sialometaplasia is not known, but it is usually preceded by trauma.
A 38yearold man with bilateral ulcerative painful lesions at the junction of the hard and soft palate was presented. Necrotizing sialometaplasia ns is a benign, selflimiting inflammatory reaction of salivary gland tissue which may. The clinical and histological similarity between this entity and a malignant lesion implies a risk of unnecessary radical treatment. Bilateral necrotising sialometaplasia bmj case reports. It is thought to be caused by ischemic necrosis death of tissue due to lack of blood supply of minor salivary glands in response to trauma. It is locally destructive, with inflammation to an area of tissue resulting in damage and ischemic necrosis. Epidemiology most patients are more than 40 years of age, with. A case report article pdf available august 2012 with 855 reads. Necrotizing sialometaplasia occurred in a 46yearold woman. Necrotizing sialometaplasia ns is a benign, ulcerative lesion, usually located towards the. This is an uncommon benign disease that typically begins with an ulcerated lesion on the hard palate and surrounding tissues. Reactive, self resolving condition, mostly affecting the palate heals within 6 10 weeks etiology is thought to be reaction to trauma or smoking in the presence of existing tissue ischemia. Often painless, the condition is selflimiting and should heal in 610 weeks.
Its clinical presentations can simulate malignancy 4, although it is a benign pathology. Necrotizing sialometaplasia, salivary glands, ulcerative lesion. Necrotising sialometaplasia is a rare, benign and selflimiting inflammatory lesion that commonly involves minor salivary glands. Necrotizing sialometaplasia ns is an inflammatory disease of benign nature that manifests. Necrotising sialometaplasia is a rare, benign inflammatory lesion primarily involving the minor salivary glands of the hard palate. Necrotising sialometaplasia, recognised by lobular infarction, necrosis, and simultaneous squamous metaplasia of ducts and acini is a well known condition. Necrotizing sialometaplasia is a rare inflammatory necrotizing reactive process that can involve minor and major salivary glands. C, bengondo messanga, nokam abena m, ntep ntep d, kenna e, and mendouga mengne c. Necrotizing sialometaplasia in a patient with buergers disease and raynauds phenomenon. Necrotizing sialometaplasia ns is a benign condition that may be found at any site in the body that contains elements of the salivary gland. Physicians should be aware of its clinical and histological traits in order to avoid unnecessary disfiguring surgery.
A case of necrotizing sialometaplasia clinically mimicking. It can represent a diagnostic dilemma and may be mistaken for a malignant neoplasm, such as mucoepidermoid carcinoma, as well as. Necrotizing sialometaplasia nsm is a benign, selfhealing lesion of salivary glands, which represents less than 1% of biopsied oral lesions. Necrotizing sialometaplasia is a rare, benign, selflimiting, necrotizing process involving the minor salivary glands, mainly the mucoserous glands of the hard palate. All subsequent reports of necrotizing sialometaplasia stress the.
Sialometaplasia arising in the ectopic salivary gland. Presentation of the lesion is that of a deep seated ulcer. There are only a few reports of the proliferative type of sialometaplasia. Necrotizing sialometaplasia ns is a self limiting inflammatory disease, that involves salivary glands, more frequently the. Necrotizing sialometaplasia versus invasive carcinoma of. Necrotizing sialometaplasia, is a benign inflammatory lesion primarily involving the minor salivary glands of the hard palate. Necrotising sialometaplasia is a benign, necrotising, selfhealing inflammatory condition categorised as idiopathic disease of salivary glands. Necrotizing sialometaplasia is a rare lesion that mimics malignant neoplasm, which is characterized by salivary gland metaplasia, necrosis, and inflammation. This selflimiting benign lesion is easily confused with malignant tumors. Classically, it involves the mucoserous glands of the hard palate.
A diagnostic dilemma jayakiran madala, venkateswararao guttikonda, rajani korlepara, sivaranjani yeluri. Necrotizing sialometaplasia is a benign inflammatory condition of the salivary gland remnants or elements, which is usually selflimiting. Necrotizing sialometaplasia ns is a benign, ulcerative lesion, usually located towards the back of the hard palate. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. To investigate the use of immunohistochemistry in distinguishing necrotizing sialometaplasia nsm from squamous cell scc and mucoepidermoid carcinoma mec by i the identification of myoepithelial cells and ii. Necrotizing sialometaplasia radiology reference article. An association with neoplasia, such as parotid tumors, false vocal cord squamous cell carcinoma, and maxillary sinus carcinoma, is also reported. Necrotizing sialometaplasia ns is a selflimiting, benign, ischemic, inflammatory disease that is most often described in the submandibular glands of dogs, with clinical and histologic features that resemble. Review of the literature on necrotizing sialometaplasia and case. Experimental study on necrotizing sialometaplasia of the palate in rats. Download fulltext pdf sialometaplasia necrotizante. Necrotizing sialometaplasia is a benign selflimiting lesion of both major and minor salivary glands although more commonly the latter.
Download fulltext pdf download fulltext pdf necrotizing sialometaplasia of palate. Necrotizing sialometaplasia is an inflammatory, rare and. Disease bioinformatics research of sialometaplasia, necrotizing has been linked to salivary gland diseases, carcinoma, metaplasia, ulcer, malignant squamous cell neoplasm. It is thought to be the result of an ischemic event of the vasculature supplying the salivary gland lobules. Necrotizing sialometaplasia ns is a rare benign inflammatory disease that affects the major and minor salivary glands. It is considered by some authors to be a distinct entity 1,2 and by others to be part of the spectrum of necrotizing sialometaplasia ns. A case report observed at the university teaching hospital of yaounde. In 1973, abrams et al first reported this condition. Brocheriou c, bertrand jch 1979 sialometaplasie necrosante.
The study of sialometaplasia, necrotizing has been mentioned in research publications which can be found using our bioinformatics tool below. Ischemia, necrotizing sialometaplasia, palate, self limiting disease. Necrotizing sialometaplasia registered dental hygienist. Necrotising sialometaplasia being an important differential for an apparent carcinoma should be excluded histologically prior. Necrotizing sialometaplasia necrotizing sialometaplasias. No treatment has been described previously either for. Sialometaplasia definition at, a free online dictionary with pronunciation, synonyms and translation. Sialometaplasia, squamous metaplasia of salivary gland lobules, is a benign condition occasionally presenting with lesions clinically simulating malignancy. Necrotizing sialometaplasia is a rare, benign inflammatory disease of the minor mucous salivary glands usually caused by glandular ischemia or trauma, that can mimic malignancy, but has a selflimiting character. It appears as an aggressive looking lesion in an adult possibly resembling squamous cell carcinoma and mucoepidermoid carcinoma. Clinical and microscopic findings show obvious similarity with a malignant neoplasm. Necrotizing sialometaplasia the journal of laryngology.
Necrotizing sialometaplasia nsm is a rare benign, inflammatory disease of both major and minor salivary glands, although. Pdf necrotizing sialometaplasia of parotid gland abram. Necrotizing sialometaplasia of tongue tanu randhawa, ipe varghese, shameena pm, sudha s, resmi g nair department of oral pathology and microbiology, government dental college, calicut 673 008, kerala. The clinical and histopathologic features of necrotizing sialometaplasia often simulate those of malignancies such as squamous cell carcinoma or salivary gland malignancy. The lesion often presents itself as a deepseated palatal ulcer with clinical and histological features similar to those of a malignant neoplasm. In the who classification of salivary gland tumors, ns is classified under the group of tumorlike lesions. Necrotizing sialometaplasia ns is a nonneoplastic inflammatory condition of the salivary glands. Necrotizing sialometaplasia is a benign, selflimited lesion of both major and minor salivary glands, although more commonly the latter. Subacute necrotizing sialadenitis sans is a selflimiting inflammatory lesion of the minor salivary glands of unknown cause. Necrotizing sialometaplasia ns was first reported in 1973 by abrams et al. To the best of our knowledge, only 22 cases of sans have been reported, mostly on salivary palatal glands. Surgical management of necrotizing sialometaplasia of palate balaji. This may occur not only in the salivary glands but also in sinusnasal tracts and the respiratory tract. We report a case of necrotizing sialometaplasia in middle aged women presenting as a nonulcerated swelling.
Necrotizing sialometaplasia of the parotid gland in a dog. Necrotizing sialometaplasia is an uncommon inflammatory condition that affects salivary glands. Most cases of necrotizing sialometaplasia appear to arise spontaneously, whereas others are associated with a history of trauma, vomiting, 18, 19 radiation therapy, or surgery. We present a case of necrotizing sialometaplasia that presented as an ugly ulcer at the junction of the soft and hard palates. Necrotizing sialometaplasia nsm is an uncommon inflammatory condition that affects salivary glands. Necrotizing sialometaplasia of hard palate a case report. Necrotising sialometaplasia, described for the first time by abrams in 19731, is a rare inflammatory pathology of accessory salivary glands. Here we report a case of necrotizing sialometaplasia in a female on left side of hard palate mimicking carcinoma.
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